Resumen de Alopurinol en las distrofias musculares progresivas
Manuel Castro Gago, F.J. Jiménez, Manuel Torres Colomer, Manuel Fuster-Siebert, J M Paz, I. Novo, José Peña Guitián
The authors treated ten children with progressive muscular dystrophy, aged from 15 months to eleven years with allopurinol. An initial study and thereafter monthly clinical evaluations were made of muscular strength, Gowers's sign and pseudohypertrophy. CPK, LDH, aldolase, GOT and serum urate were determined monthly, and electromyography was carried out bimonthly. In three patients a complete recovery of strength and Gowers's sign were found and at the same time there was a diminsihed pseudohypertrophy; the average age was three years and four months. In four patients a partial recovery was found; the age average was nine years and four months. In three patients there was no response to treatment. This group (mean age 10 yr) showed contraction and had deformities. No variations on monthly controls of CPK, LDH, aldolase and GOT were observed. On the basis of these facts the authors opinion is that allopurinol is an effective drug in the treatment of progressive muscular dystrophy and that the efficacy is improved when treatment is initiated early and, of course, before patients present deformities and contractures.
