Evaluation of genotoxic and cytotoxic effects of anorectic drugs in lymphocytes of obese people

• da Silva, Cristiano José ^[1] ; dos Santos, José Ernesto ^[2] ; Takahashi, Catarina Satie ^[3]
  1. [1] IFG - Câmpus Goiás
  2. [2] Department of Medical Clinic, Faculty of Medicine of Ribeirão Preto (FMRP), São Paulo University (USP), Ribeirão Preto-SP, Brazil
  3. [3] Department of Genetics, Faculty of Medicine of Ribeirão Preto (FMRP), São Paulo University (USP), Ribeirão Preto-SP, Brazil Department of Biology, Faculty of Philosophy Sciences and Letters of Ribeirão Preto (FFCLR), São Paulo University (USP), Ribeirão Preto-SP, Brazil

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• Localización: RBONE - Revista Brasileira de Obesidade, Nutrição e Emagrecimento, ISSN-e 1981-9919, Vol. 13, Nº. 78, 2019, págs. 258-266
• Idioma: inglés
• Títulos paralelos:
  • Avaliação dos efeitos genotoxicos e citotóxicos de medicamentos anoréticos em linfócitos de pessoas obesas
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• Resumen
  • English

    Obesity is a major public health concern nowadays, as the risk of developing cancer and other chronic diseases has increased considerably in this population. Using in vitro tests (Comet Assay and Micronucleus Test), we evaluated whether lymphocytes from obese individuals (BMI: 40-62 kg / m2) are sensitive to genotoxic and cytotoxic damage when exposed to anorexigenics sibutramine, femproporex and phytotherapics Cordia ecalyculata and Echinodorus grandiflorus. We found that both possessed weak genotoxic activity and did not detect cytotoxic activity or interference in the cell division mechanisms of lymphocytes among obese individuals.

  • português

    A obesidade é uma das principais preocupações de saúde pública atualmente, pois o risco de desenvolver câncer e outras doenças crônicas aumentou consideravelmente nessa população. Utilizando testes in vitro (Ensaio Cometa e Teste de Micronúcleo), avaliamos se linfócitos de indivíduos obesos (IMC: 40-62 kg / m2) são sensíveis a danos genotóxicos e citotóxicos quando expostos aos anorexígenos sibutramina, femproporex e fitoterápicos Cordia ecalyculata e Echinodorus grandiflorus. Descobrimos que ambos possuem fraca atividade genotóxica e não detectamos atividade citotóxica ou interferência nos mecanismos de divisão celular de linfócitos de indivíduos obesos. ABSTRACTEvaluation of genotoxic and cytotoxic effects of anorectic drugs in lymphocytes of obese peopleObesity is a major public health concern nowadays, as the risk of developing cancer and other chronic diseases has increased considerably in this population. Using in vitro tests (Comet Assay and Micronucleus Test), we evaluated whether lymphocytes from obese individuals (BMI: 40-62 kg / m2) are sensitive to genotoxic and cytotoxic damage when exposed to anorexigenics sibutramine, femproporex and phytotherapics Cordia ecalyculata and Echinodorus grandiflorus. We found that both possessed weak genotoxic activity and did not detect cytotoxic activity or interference in the cell division mechanisms of lymphocytes among obese individuals.