Distribution in tissues and effects by acute hypoxia on angiotensin I converting enzyme activity in guinea pig and chicken

• Autores: C. Cuadrillero, M. J. Polanco, Maria Teresa Agapito Serrano, J. M. Recio
• Localización: Revista española de Fisiología, ISSN 0034-9402, Vol. 40, Nº. 3, 1984, págs. 371-374
• Idioma: inglés
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• Resumen

  • Angiotensin I converting enzyme activity was measured in homogenates of guinea pig and chicken organs (lung, kidney, heart, ileum, diaphragm and liver), using a spectrophotometric assay for hydrolysis of hippuryl-L-histidyl-L-leucine. High specific activities were found in lung, kidney and diaphragm, but the highest corresponded to guinea pig lung and chicken kidney. Acute hypoxia decreased angiotensin I converting enzyme activity in guinea pig lung and chicken diaphragm, but the changes in kidney were considered non-significant in both the guinea pig and chicken.