Effects of Dietary Components During and After Concomitant Chemoradiotherapy, Radiotherapy, or Sequential Chemoradiotherapy to the Abdominopelvic Area

• Laura Flores Cisneros ; Denisse Castro Eguiluz ; Diana Yolanda Reyes Barretero ; Emigdio Jaimes Alpízar ; Claudia Cano Blanco ^[3] ; Carlos Avendaño Pérez ^[1] ; Berenice Carbajal López ^[3] ; Miriam S. Sánchez López ; Aida Mota García ; Dolores Gallardo Rincón ; Marce Inzunza Soto ^[2] ; Claudia Hernandez Quintero ^[2] ; Lucely del Rosario Cetina Pérez
  1. [1] Instituto Politécnico Nacional

     Instituto Politécnico Nacional

     México

     
  2. [2] Universidad Autónoma de Sinaloa

     Universidad Autónoma de Sinaloa

     México

     
  3. [3] Instituto Nacional de Cancerología, MEX

  Mostrar afiliaciones +
• Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 70, Nº. 3, 2018, págs. 126-129
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • Radiotherapy is a fundamental part of the treatment of pelvic neoplasms. Up to 90% of patients develop gastrointestinal symptoms as a result of acute injury to the small and large intestine, particularly in the mucosa. Radiotherapy leads to atrophy of the intestinal epithelium, acute crypt inflammation, inflammatory infiltration of the epithelium, malabsorption of lactose, and biliary salts as well as alterations in pancreatic enzymes and biliary salts, resulting in the malabsorption syndrome and dysbiosis. The most commonly reported symptoms of pelvic radiation disease include changes in bowel habits (94%), decreased fecal consistency (80%), frequency of bowel movements (74%), bowel urgency (39%), and fecal incontinence (37%). Although nutritional interventions with dietary modifications have been reported to prevent and treat gastrointestinal symptoms, the evidence remains inconclusive. (REV INVES CLIN. 2018;70:126-9)