Nitric Oxide and Iron Signaling Cues Have Opposing Effects on Biofilm Development in Pseudomonas aeruginosa

• Xinyi Zhu ^[1] ; Scott A. Rice ^[1] ; Nicolas Barraud ^[2]
  1. [1] Singapore Centre for Environmental Life Sciences Engineering

     Singapore Centre for Environmental Life Sciences Engineering

     Singapur

     
  2. [2] Institut Pasteur

     Institut Pasteur

     Francia

     
• Localización: Applied and Environmental Microbiology, ISSN 0099-2240, Vol. 85, Nº 3, 2019
• Idioma: inglés
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• Resumen

  • Nitric oxide (NO), which induces biofilm dispersal, is a promising strategy for biofilm control in both clinical and industrial contexts. However, competing environmental signals may reduce the efficacy of NO. The results presented here suggest that the presence of iron represents one such environmental cue that antagonizes the activity of NO as a biofilm-dispersing agent. Based on this understanding, we developed a strategy to enhance dispersal by combining NO with an iron-scavenging agent. Overall, this study links two important environmental signals, iron and NO, with their roles in biofilm development and suggests new ways for improving the use of NO in biofilm control strategies.