Resumen de Teduglutide achieves no need for home parenteral nutrition in patient with short bowel syndrome: 18-month treatment report
Francisca Sánchez Rubio, Sergio Plata Paniagua, Marca Díaz Rangel, José Marco Del Río, Ismael Pérez Alpuente, Sonia Ruiz Sánchez
Patient diagnosed with Ulcerative Colitis with inflammatory pattern, causing many outbreaks and cases of intestinal subocclusion leading to numerous complications requiring hospitalization and a torpid clinical course. He underwent many resection surgeries, and finally a permanent ileostomy was constructed. It was prescribed Total Parenteral Nutrition (TPN) and after clinical stabilization, the patient was discharged to recover his nutritional status continuing with TPN at home. Home Parenteral Nutrition (HPN) started for during five days a week. After two months, the endocrinologist requested treatment with subcutaneous teduglutide 0.05 mg/kg/day. Teduglutide treatment resulted in reductions from baseline in HPN administration requirements to four days per week. After three and a half months of treatment, HPN administration requirements decreased to two days per week; and after six months of treatment, the patient has weaned off HPN. The patient has progressed favorably keeping an optimal nutritional status. For the first time, we report the results of 18-month treatment with teduglutide (from June 2016 to December 2017) and describe the clinical course of a patient with Short Bowel Syndrome (SBS) who manages to permanently wean off the administration of parenteral support (PS) from month sixth of treatment to date
