The assessment of surgical and non-surgical treatment of stage II medication-related osteonecrosis of the jaw

• Takanori Eguchi ^[2] ; Ikuyo Kanai ^[2] ; Akihiko Basugi ^[2] ; Yukinaga Miyata ^[2] ; Minako Inoue ^[1] ; Yoshiki Hamada ^[1]
  1. [1] Tsurumi University

     Tsurumi University

     Naka Ku, Japón

     
  2. [2] Department of Oral and Maxillofacial Surgery, Toshiba Rinkan Hospital, Sagamihara, Japan
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 22, Nº. 6 (November ), 2017
• Idioma: inglés
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• Resumen

  • Non-surgical treatment has generally been recommended for stage II medication-related osteonecrosis of the jaw (MRONJ) in preference to surgery. However, non-surgical treatment is not empirically effective. The aim of this study was to evaluate whether surgical or non-surgical treatment leads to better outcomes for stage II MRONJ.

    In this retrospective study, surgery was performed in a total of 28 patients while 24 patients underwent non-surgical treatment. The outcomes of both treatment approaches after 6 months were evaluated and statistically compared. In addition, risk factors for surgical and non-surgical treatments were assessed for each.

    Surgical treatment in 25 patients (89.3%) resulted in success, with failure in 3 patients (10.7%). Non-surgical treatment was successful for 8 patients (33.3%) and failed in 16 patients (66.7%). There was therefore a significant difference between surgical and non-surgical treatment outcomes (P<0.01). Regarding risk factors, in non-surgical treatment primary diseases, medications, and drug holiday had a significant effect on outcomes (P<0.01). Risk factors for surgical treatment could not be clarified.

    Surgical treatment is more effective than non-surgical treatment for stage II MRONJ, and drug holiday, primary disease, and medication constitute risk factors in non-surgical treatment.