Resumen de Antimicrobial prophylaxis for prevention of surgical infection
Erika Esteve, Ariadna Padullés Zamora, Miquel Pujol Rojo, Sara Cobo Sacristán, Ramón José Jódar Masanés
Surgical site infection is one of the most common healthcare-associated infection in which a wound infection occurs after an invasive (surgical) procedure. Method: This review provides practical recommendations and basic principles involved in the use of prophylactic antibiotic such as antibiotic dosing, the optimal time for administration of preoperative doses, best administration route, prophylaxis duration, need for intraoperative redosing and auditory process to evaluate the program adherence for optimizing the use of antibiotics. Results: The prophylactic antimicrobial agent should be administered at such a time to provide serum and tissue concentrations exceeding the minimum inhibitory concentration for the probable organisms associated with the procedure. The optimal time for administration of preoperative doses is within 30 or 60 minutes before surgical incision, except the agents with long elimination half-life whose administration should begin within 60 or 120 minutes before it. Intraoperative redosing is needed if the duration of the procedure exceeds two half-lives. The duration of antibiotic prophylaxis involves a single dose or continuation for 24 or 48 hours. Compliance of the antimicrobial guidelines should be measured to ensure protocol adherence. Conclusion: Optimal surgical prophylaxis administration should be considered a basic tool for prevention of surgical-site infections and related adverse effects
