Oral Nutrient Supplementation and Cognitive Function—Reply

• Autores: Emily Chew, Lenore Launer, Paul Bernstein
• Localización: JAMA: the journal of the American Medical Association, ISSN 0098-7484, Vol. 315, Nº. 5, 2016, págs. 516-517
• Idioma: inglés
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• Resumen

  • In Reply The AREDS2 trial provided a unique opportunity to evaluate the effects of oral supplementation on cognition. The limitations of our study included testing in a well-nourished, well-educated, select population affected with age-related macular degeneration. We noted the restricted generalizability of the results to this population and the possibility that the doses and ratios of various omega-3 LCPUFAs were inappropriate.

    Concerning the remarks of Dr Renzi-Hammond and colleagues, our study was designed to evaluate the main effects of the individual nutrients, specifically omega-3 LCPUFAs. We agree that this was not a placebo-controlled study. We described the fact that the majority of participants were using some form of AREDS supplements that contained antioxidant vitamins C, E, and beta-carotene, which were tested in previous trials of cognition with no definitive beneficial effects.