Resumen de Chapter Seventeen - Tumor Microenvironment as Target in Cancer Therapy
Reuven Reich, Claudiu T. Supuran, Eli Breuer
Abstract The role of the microenvironment is of critical importance during the initiation and progression of carcinogenesis, both for understanding cancer biology and exploiting new knowledge for improved diagnostics and therapeutics at the cellular and molecular level. This summary emphasizes the most dynamic aspects of the microenvironment, namely tumor promoting enzymes and their inhibition. The enzymes mentioned are matrix metalloproteinases (MMPs) degrading connective tissue and carbonic anhydrases regulating pH level in the extracellular space. Additional enzymes reviewed are ectonucleotidases, such as autotaxin (ATX), CD73, and CD39. There is a short introduction to carbamoylphosphonates, inhibitors that regulate in vivo three kinds of zinc enzymes, MMP2, CAIX, and ATX, incapacitating the cancer.
