Resumen de Chapter Eleven - Urate Crystal Deposition Disease and Gout—New Therapies for an Old Problem
Jean-Luc Girardet, Jeffrey H. Miner
Abstract Gout is a chronic, inflammatory arthritic condition resulting from monosodium urate crystal deposition in joints and tissues, which develop because of high levels of serum uric acid. Gout treatment includes short-term approaches for acute gout attacks (gout flares) and long-term approaches for treating hyperuricemia. Acute gout therapy focuses on rapid inhibition of pain and inflammation resulting from the inflammatory response to monosodium urate crystal deposition. Most commonly prescribed acute gout therapies in the United States are NSAIDs, colchicine, and corticosteroids. Optimal treatment of gout also includes approaches to address chronically high uric acid levels. Therapeutic approaches to address gout-associated hyperuricemia include inhibiting production of uric acid using xanthine oxidase inhibitors, degrading uric acid with recombinant uricase, and increasing uric acid excretion using older uricosuric agents and newer selective uric acid reabsorption inhibitors. The recent surge of research in this area brings with it the potential for new targets and therapeutic combinations.
