Ubiquitinated inclusions and neuronal cell death

• I. Lang-Rollin ^[1] ; H. Rideout ^[1] ; L. Stefanis ^[1]
  1. [1] Columbia University

     Columbia University

     Estados Unidos

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 18, Nº. 2, 2003, págs. 509-517
• Idioma: inglés
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• Resumen

  • Ubiquitinated inclusions and selective neuronal cell death are considered the pathological hallmarks of Parkinson’s disease and other neurodegenerative diseases. Recent genetic, pathological and biochemical evidence suggests that dysfunction of ubiquitin-dependent protein degradation by the proteasome might be a contributing, if not initiating factor in the pathogenesis of these diseases. In neuronal cell culture models inhibition of the proteasome leads to cell death and formation of fibrillar ubiquitin and a- synuclein-positive inclusions, thus modeling some aspects of Lewy body diseases. The processes of inclusion formation and neuronal cell death share some common mechanisms, but can also be dissociated at a certain level.