Review: circulating tumor cells in the practice of breast cancer oncology

• R. Ramos-Medina ^[1] ; F. Moreno ^[2] ; S. Lopez-Tarruella ^[1] ; M. del Monte-Millán ^[1] ; I. Márquez-Rodas ^[1] ; E. Durán ^[1] ; Y. Jerez ^[1] ; J. A. Garcia-Saenz ^[2] ; I. Ocaña ^[1] ; S. Andrés ^[1] ; T. Massarrah ^[1] ; M. González-Rivera ^[1] ; M. Martin ^[1]
  1. [1] Instituto de Investigación Sanitaria Gregorio Marañón

     Instituto de Investigación Sanitaria Gregorio Marañón

     Madrid, España

     
  2. [2] Hospital Clínico San Carlos de Madrid

     Hospital Clínico San Carlos de Madrid

     Madrid, España

     
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 18, Nº. 8 (August 2016), 2016, págs. 749-759
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The primary cause of tumor-related death in breast cancer is still represented by distant metastasization. The dissemination of tumor cells from the primary tumor to distant sites through bloodstream cannot be early detected by standard imaging methods. Circulating tumor cells (CTCs) play a major role in the metastatic spread of breast cancer. Different analytical systems for CTCs isolation and detection have been developed and novel areas of research are directed towards developing assays for CTCs molecular characterization. This review describes the current state of art on CTCs detection techniques and the present and future clinical implications of CTCs enumeration and characterization.