Pain and Intramuscular Release of Algesic Substances in the Masseter Muscle After Experimental Tooth-Clenching Exercises in Healthy Subjects

• Autores: Andreas Dawson, Bijar Ghafouri, Björn Gerdle, Thomas List, Peter Svensson, Malin Ernberg
• Localización: Journal of Oral & Facial Pain and Headache, ISSN-e 2333-0376, ISSN 2333-0384, Vol. 27, Nº. 4, 2013, págs. 350-360
• Idioma: inglés
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  • Aims: To investigate whether experimental tooth clenching leads to a release of algesic substances in the masseter muscle. Methods: Thirty healthy subjects (16 females, 14 males) participated. During two sessions, separated by at least 1 week, intramuscular microdialysis was performed to collect masseter muscle 5-hydroxytryptamine (5-HT) and glutamate as well as the metabolic markers pyruvate and lactate. Two hours after the start of microdialysis, participants were randomized to a 20-min repetitive experimental tooth-clenching task (50% of maximal voluntary contraction) or a control session (no clenching). Pain and fatigue were measured throughout. The Friedman and Wilcoxon tests were used for statistical analyses. Results: No alterations were observed in the concentrations of 5-HT, glutamate, pyruvate, and lactate over time in the clenching or control session, or between sessions at various time points. Pain (P < .01) and fatigue (P < .01) increased significantly over time in the clenching session and were significantly higher after clenching than in the control session (P < .01). Conclusion: Low levels of pain and fatigue developed with this experimental tooth-clenching model, but they were not associated with an altered release of 5-HT, glutamate, lactate, or pyruvate. More research is required to elucidate the peripheral release of algesic substances in response to tooth clenching. J Orofac Pain 2013;27:350–360. doi: 10.11607/jop.1170