Bacterial Profile and Burden of Periodontal Infection in Subjects With a Diagnosis of Acute Coronary Syndrome

• Autores: Ola Ohlsson, G. Rutger Persson, Stefan Renvert, Thomas Pettersson
• Localización: Journal of periodontology, ISSN 0022-3492, Vol. 77, Nº. 7, 2006, págs. 1110-1119
• Idioma: inglés
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• Resumen

  • Bacterial Profile and Burden of Periodontal Infection in Subjects With a Diagnosis of Acute Coronary Syndrome Stefan Renvert,* Thomas Pettersson,† Ola Ohlsson,*† and G. Rutger Persson‡§ *Department of Health Sciences, Kristianstad University, Kristianstad, Sweden.

    †Department of Medicine, Central Hospital, Kristianstad, Sweden.

    ‡Department of Periodontology and Fixed Prosthodontics, Division of Oral Microbiology, University of Berne, Berne, Switzerland.

    §Departments of Periodontology and Oral Medicine, University of Washington, Seattle, WA.

    Correspondence: Dr. G. Rutger Persson, Department of Periodontology and Fixed Prosthodontics, Division of Oral Microbiology, University of Bern, CH 3010 Bern, Switzerland. Fax: 41-31-632-8608; e-mail: rutger.persson@zmk.unibe.ch.

    Background: Periodontitis has been identified as a potential risk factor in cardiovascular diseases. It is possible that the stimulation of host responses to oral infections may result in vascular damage and the inducement of blood clotting. The aim of this study was to assess the role of periodontal infection and bacterial burden as an explanatory variable to the activation of the inflammatory process leading to acute coronary syndrome (ACS).

    Methods: A total of 161 consecutive surviving cases admitted with a diagnosis of ACS and 161 control subjects, matched with cases according to their gender, socioeconomic level, and smoking status, were studied. Serum white blood cell (WBC) counts, high- and low-density lipoprotein (HDL/LDL) levels, high-sensitivity C-reactive protein (hsC-rp) levels, and clinical periodontal routine parameters were studied. The subgingival pathogens were assayed by the checkerboard DNA-DNA hybridization method.

    Results: Total oral bacterial load was higher in the subjects with ACS (mean difference: 17.4 × 105; SD: 10.8; 95% confidence interval [CI]: 4.2 to 17.4; P <0.001), and significant for 26 of 40 species including Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola. Serum WBC counts, hsC-rp levels, Streptococcus intermedius, and Streptococcus sanguis, were explanatory factors to acute coronary syndrome status (Nagelkerke r2 = 0.49).

    Conclusion: The oral bacterial load of S. intermedius, S. sanguis, Streptococcus anginosus, T. forsythensis, T. denticola, and P. gingivalis may be concomitant risk factors in the development of ACS.

    KEYWORDS: Infection, myocardial infarction, periodontitis; Porphyromonas gingivalis, risk, streptococci Cited by Stefan Renvert, Ahmad Aghazadeh, Hadar Hallström and Gösta Rutger Persson. (2014) Factors related to peri-implantitis - a retrospective study. Clinical Oral Implants Research 25:10.1111/clr.2014.25.issue-4, 522-529.

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