Resumen de Long-life supplementation with atenolol converts the heart and skeletal muscle unsaturation of mitochondrial membranes of mice into those of ten fold longer-lived mammals. Effects on mean and maximum longevity

Alexia Gómez Rodriguez, Alba Naudí, Reinald Pamplona, Gustavo Barja de Quiroga Losada

• The long--�]term effects of atenolol in drinking water throughout the whole lifespan (3.3 years) of a mammal (128 C57BL/6 male mice--�]SPF) were studied for the first time.

  We observed beneficial aging--�]related changes:

  decreases in the degree of unsaturation of mitochondrial membranes and of the 22:6n--�]3 fatty acid, an increase in oleic acid, as well as decreases in protein oxidation, glycoxidation and lipoxidation and oxidative damage in mtDNA in heart and skeletal muscle mitochondria.

  However, a secondary effect of the drug only in old animals was detected that agrees with recent meta--�]analyses in human patients