Agranulocitosis por metamizol: Descripción de un caso

• Autores: F. I. Torres Bondia, J. Guevara Serrano, G. Carmona Ibáñez, Mª Pilar Ortega García, Eduardo López Briz
• Localización: Atención Farmacéutica, ISSN 1139-7357, Vol. 2, Nº. 3, 2000, págs. 259-262
• Idioma: español
• Títulos paralelos:
  • Agranulocytosis by metamizol: A case description
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• Resumen

  • It is described a case of agranulocytosis in a patient that needed a surgical intervention. The patient is a 79-year-old woman diagnosed with colon neoplasia pending surgery who enters the hospital. Her personal antecedents presented: repetitive bronchitis, arterial hypertension and habitual constipation. The analytics of her entrance were normal. The initial pharmacological treatment was composed of 2 g of metamizol every eight hour sand 50 mg of ranitidine every eight hours; both by intravenous route. After six days elapsed since her entrance, it is decided to surgically intervene her using 2 g of metamizol every six hours by intravenous route as an analgesic treatment. Four days after the intervention, the hemogram evidenced a supposed agranulocytosis, possibly by the metamizol, being confirmed by practicing a medulla ossium suction. The treatment was initiated with filgrastim on a dose of 300 mg/day. After the resolution of the agranulocytosis, after ten days of treatment, the patient was dismissed