Resumen de Dental and toungue staining related to imipenem/cilastatin

Hector José Mozo Peñalver, Cristina Martínez Roca

• Objective: Description of a dental and tongue staining case related to carbapenems imipenem/cilastatin treatment. Method: Review and monitoring of the clinical case and the evaluation of the adverse reaction by the Karch-Lasagna algorithm. Results: A 17-year-old woman diagnosed with acute pyelonephritis treated with imipenem/cilastatin. After two weeks of starting treatment with imipenem/cilastatin she observed yellow staining of tongue and teeth so she referred to a dental clinic. The tongue discoloration decreased until disappeared. The adverse reaction was considered as probable on applying the Karch-Lasagna algorithm. Yellow card was submitted to the Regional Pharmacovigilance centre. Conclusion: Although the overall incidence of this effect is low, it may be alarming for the patient and may require dental care. We considered it was necessary to report this case and notify the adverse reaction, since there is few published information and is considered a widely used antibiotic