Mortality Risk in Older Men Associated with Changes in Weight, Lean Mass, and Fat Mass

• Autores: Christine G. Lee, Edward J. Boyko, Carrie M. Nielson, Marcia L. Stefanick, Douglas C. Bauer, Andrew R. Hoffman, Thuy-Tien L. Dam, Jodi A. Lapidus, Peggy M. Cawthon, Kristine E. Ensrud, Eric S. Orwoll
• Localización: Journal of the American Geriatrics Society, ISSN 0002-8614, Vol. 59, Nº. 2, 2011, págs. 233-240
• Idioma: inglés
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• Resumen

  • OBJECTIVES: To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men.

    DESIGN: Longitudinal cohort study.

    SETTING: Six U.S. clinical centers.

    PARTICIPANTS: Four thousand three hundred thirty-one ambulatory men aged 65 to 93 at baseline.

    MEASUREMENTS: Repeated measurements of body weight and total lean and fat mass were taken using dual-energy X-ray absorptiometry 4.6 ± 0.4 years apart. Percentage changes in these measures were categorized as gain (+5%), loss (�5%), or stable (-5% to +5%). Deaths were verified centrally according to death certificate reviews, and proportional hazard models were used to estimate the risk of mortality.

    RESULTS: After accounting for baseline lifestyle factors and medical conditions, a higher risk of mortality was found for men with weight loss (hazard rat (HR)=1.84, 95% confidence interval (CI)=1.50�2.26), total lean mass loss (HR=1.78, 95% CI=1.45�2.19), and total fat mass loss (HR=1.72, 95% CI=1.34�2.20) than for men who were stable for each body composition measure. Men with total fat mass gain had a slightly greater mortality risk (HR=1.29, 95% CI=0.99�1.67) than those who remained stable. These associations did not differ according to baseline age, obesity, or self-reported health status (P for interactions >.10), although self-reported weight loss intent altered mortality risks with total fat mass (P for interaction=.04) and total lean mass (P for interaction=.09) change.

    CONCLUSION: Older men who lost weight, total lean mass, or total fat mass had a higher risk of mortality than men who remained stable.