Enfermedades autoinmunes asociadas en pacientes pediátricos con diabetes mellitus tipo1 en función de su grupo genético HLA-DQ

• M. A. García Cabezas ^[2] ; Patricio Giralt Muiña ^[3] ; Pedro Benito López ^[1]
  1. [1] Hospital Reina Sofía

     Hospital Reina Sofía

     Tudela, España

     
  2. [2] Servicio de Pediatría, Hospital General
  3. [3] Fundación de Castilla la Mancha para la Diabetes

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• Localización: Revista española de pediatría: clínica e investigación, ISSN 0034-947X, Vol. 66, Nº. 2, 2010, págs. 85-90
• Idioma: español
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• Resumen

  • Background and objetive. Our hypothesis is that there is a relationship between the short term outcomes of pediatric patients with type I diabetes mellitus, their HLA-DQ genotypes and the autoimmune associated diseases. Patients and methods. We performed a descriptive epidemiologic study of 129 children and adolescents under 16 years old with type 1 diabetes mellitus. We studied their HLA DQ genotypes and classified them into groups of diabetogenic risk. It was examined general parameters in the onset diabetes mellitus type 1 and the search for the appearance of the autoimmune associated diseases during the monitoring period of 3 years. Results. The 93.8% of our patients had diabetes-risk HLA-DQ genotypes. Onset of the disease occurred earlier in patients that belonged to risk group III. The main autoimmune associated diseases, autoimmune thyroiditis and celiac disease, are more common in our diabetic patients than in people who are not diabetic. Conclusions. Patients in risk group III debut with lower age. We found a high prevalence autoimmune associated diseases, autoimmune thyroiditis and celiac disease, in our type 1 diabetes population.