Serum Lipoproteins in Overweight/Obese Postmenopausal Women: A One-Year Exercise Trial

• Autores: Manish Mohanka, Susan R. Heckbert, Melinda Irwin, Bess Sorensen, Yutaka Yasui
• Localización: Medicine & Science in Sports & exercise: Official Journal of the American College of Sports Medicine, ISSN 0195-9131, Vol. 38, Nº. 2, 2006, págs. 231-239
• Idioma: inglés
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• Resumen

  • Introduction: This analysis was conducted to study the effect of a 1-yr moderate-intensity aerobic exercise program on serum lipoproteins among overweight/obese postmenopausal women.

    Methods: We randomized 173 sedentary (mean [latin capital V with dot above]O2max = 20.2 mL[middle dot]kg-1[middle dot]min-1), overweight/obese women (body mass index (BMI) 25.0-42.0 kg[middle dot]m-2 or body fat > 33% if BMI 24.0-25.0) aged 50-75 yr, not using hormone therapy, living in the Seattle area, to an exercise intervention or stretching control group. The exercise intervention included facility and home-based exercise (45 min, 5 d[middle dot]wk-1 of moderate-intensity sports or recreational exercise). Total cholesterol (TC), triglycerides, and high-density lipoprotein (HDL) were determined by chemical assay; low-density lipoprotein (LDL) was then calculated.

    Results: Of the 173 women, 170 (98.3%) completed the study with exercisers averaging 176 (SD 91) min[middle dot]wk-1 of moderate- to vigorous-intensity (60%-75% HRmax) exercise, expending approximately 3828 kJ[middle dot]wk-1 (SD 2053). Exercisers, compared with stretchers, significantly increased their [latin capital V with dot above]O2max (+11%, P<0.001) and lost more body weight (-1.4 kg, P < 0.05), DEXA-% total body fat (-1.0, P < 0.005), L4-5 computed tomography intraabdominal fat (-8.6 cm2, P < 0.05) and subcutaneous abdominal fat (-28.8 cm2, P < 0.005) after 12 months. Mean (SD) baseline lipoprotein levels for TC, LDL, HDL, and triglycerides were 231 (39), 152 (39), 52 (12), and 135 (65) mg[middle dot]dL-1, respectively. We observed no significant change in serum lipoprotein levels among exercisers compared with stretchers at either 3 or 12 months postrandomization. We did not observe a statistically significant effect of exercise on serum lipoproteins in subgroups that changed their intraabdominal and subcutaneous fat, percent total body fat, or [latin capital V with dot above]O2max the most, or that adhered to the exercise regimen the most over 1 yr.

    Conclusion: It appears that a year long moderate-intensity exercise program alone does not significantly alter serum lipoprotein levels among overweight/obese postmenopausal women