Nanoengineered delivery of RNA: impact on brain diseases and COVID-19 vaccination
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http://hdl.handle.net/10347/32336
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Título: | Nanoengineered delivery of RNA: impact on brain diseases and COVID-19 vaccination |
Autor/a: | López Borrajo, Mireya |
Dirección/Titoría: | Alonso Fernández, María José |
Centro/Departamento: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación e Desenvolvemento de Medicamentos |
Palabras chave: | nanotechnology | genetic medicine | RNA | central nervous system diseases | vaccines | |
Data: | 2023 |
Resumo: | Genetic therapies show great potential for treating various diseases through modulation of the expression of specific genes. Their effective delivery is crucial, particularly for challenging conditions like CNS diseases and SARS-CoV-2 vaccines. Here, we used nanotechnology as a fundamental tool for RNA delivery. First, we engineered an ionizable nanoemulsion designed for brain diffusion and delivery of RNA. Second, we explored nanocarriers loaded with siRNA for brain delivery, exploring their performance following alternative administration routes. Finally, we encapsulated mRNAs derived from SARS-CoV-2 within nanoemulsions and polymeric nanocapsules, achieving significant cellular immune responses. |
Data de Embargo: | 2024-12-22 |
URI: | http://hdl.handle.net/10347/32336 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
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- Área de Ciencias da Saúde [1262]
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