In vitro and in vivo evaluation of lipidic nanosystems for cancer therapy
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/31284
Ficheiros no ítem
Metadatos do ítem
Título: | In vitro and in vivo evaluation of lipidic nanosystems for cancer therapy |
Autor/a: | Cascallar Castro, María |
Dirección/Titoría: | Fuente Freire, María de la Sánchez Piñón, Laura Elena |
Centro/Departamento: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular |
Palabras chave: | nanomedicine | spheroids | organ-on-a-chip | zebrafish | cancer | |
Data: | 2023 |
Resumo: | Since the FDA-approval of the first nanomedicines, the development of innovative therapeutic approaches based on nanotechnology has been continuously growing in the biomedical area. In the field of cancer, novel therapeutic strategies are urgently need, and nanomedicine can strongly contribute to respond to this demand. It is also necessary to improve the translation of novel nanomedicines by implementing preclinical tools that that mimics efficiently the tumor structure for a correct evaluation of the therapy and allow a better understanding of their efficacy and toxicity prior testing in advanced models of the disease. In this sense, the main objective of this thesis is the use of advanced in vitro and alternative in vivo models, for the preclinical study of previously developed sphingomyelin nanoemulsions for cancer treatment. Overall, this thesis proves the versatility of sphingomyelin nanosystems for being loaded with different types of therapeutic molecules and decorated with specific ligands for cancer treatment, and, importantly, the critical role of 3D in vitro models, static and non-static, and zebrafish embryos, to evaluate the behavior and efficacy of cancer nanomedicines. |
Data de Embargo: | 2024-10-11 |
URI: | http://hdl.handle.net/10347/31284 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
-
- Área de Ciencias da Saúde [1262]
O ítem ten asociados os seguintes ficheiros de licenza: