Selective recognition of threeway DNA junctions with designed peptidomimetics
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http://hdl.handle.net/10347/30922
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Título: | Selective recognition of threeway DNA junctions with designed peptidomimetics |
Autor/a: | Alcalde Ordóñez, Ana |
Dirección/Titoría: | Vázquez Sentís, Marco Eugenio Vázquez López, Miguel |
Centro/Departamento: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Ciencia e Tecnoloxía Química |
Palabras chave: | DNA structures | drugs | peptide ligands | stereoselective synthesis of dinuclear Cu(II) | |
Data: | 2023 |
Resumo: | Non-canonical DNA structures, such as three-way DNA junctions (3WJs), formed during DNA replication, have emerged as promising alternative DNA targets for the development of new drugs with attractive therapeutic properties. In this context, supramolecular helicates have shown high selectivity and binding affinity for 3WJs, but their use in this field is hampered by the lack of synthetic versatility and a general strategy to their enantioselective synthesis. In this thesis, we describe the stereoselective self-assembly of helicates derived from peptide ligands equipped with 2,2’-bipyridine coordinating residues, as well as the implementation of a new strategy that relies on the cooperative 3WJ-binding mechanism of natural proteins, to yield new systems with selective 3WJs recognition properties. |
Data de Embargo: | 2024-07-13 |
URI: | http://hdl.handle.net/10347/30922 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
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- Área de Ciencias [953]
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