Nanosystems for the intracellular delivery of antitumoral molecules
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/29417
Ficheiros no ítem
Metadatos do ítem
Título: | Nanosystems for the intracellular delivery of antitumoral molecules |
Autor/a: | Lores Touriño, Saínza |
Dirección/Titoría: | de la Fuente Freire, María |
Centro/Departamento: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular |
Palabras chave: | Nanomedicine | Cancer | Intracellular delivery | Gene therapy | Small molecules | Monoclonal antibodies | |
Data: | 2022 |
Resumo: | Cancer remains the second leading cause of death, which highlights the need to develop novel therapeutic approaches. Personalized medicine acts on specific targets of cancer cells, of which 60% are intracellular. Small molecules, which present the ability to cross biological membranes can target only the 10% of the human genome. In contrast, macromolecules, such as gene therapies and monoclonal antibodies can solve this drawback. However, an effective vector is needed to facilitate its penetration through the cellular membrane. With this in frame, the main objective of this thesis is the optimization of previously developed sphingomyelin nanosystems to associate different antitumoral agents, from small molecules to macromolecules such as plasmid DNAs, and monoclonal antibodies to achieve their intracellularly delivery into cancer cells and promote their death. Overall, this thesis proves the potential of sphingomyelin nanosystems to associate different types of antitumoral drugs, including gene therapies and antibodies, and to promote their intracellular delivery. Evidence of the enhanced therapeutic potential of this approach is provided in several preclinical models (pancreatic tumour spheroids, zebrafish embryo and mice). |
Data de Embargo: | 2023-10-25 |
URI: | http://hdl.handle.net/10347/29417 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
-
- Área de Ciencias da Saúde [1262]
O ítem ten asociados os seguintes ficheiros de licenza: