Neuroprotective effects of potent antioxidant molecules isolated from Bifurcaria bifurcata and Codium tomentosum in a in vitro and in vivo Parkinson Disease model

• Autores: Joana Rita Martins da Silva
• Directores de la Tesis: Rui Filipe Pinto Pedrosa (dir. tes.), María Amparo Alfonso Rancaño (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2021
• Idioma: inglés
• Tribunal Calificador de la Tesis: Luis Miguel Botana López (presid.), Vitor Manuel Oliveira Vasconcelos (secret.), Jesús Gaudencio Aquino Martínez (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencias Marinas, Tecnología y Gestión por la Universidad de A Coruña; la Universidad de Santiago de Compostela; la Universidad de Vigo; Universidade de Aveiro(Portugal); Universidade de Porto(Portugal); Universidade de Trás-os-Montes e Alto Douro(Portugal) y Universidade do Minho (Portugal)
• Materias:
  • Ciencias de la vida
    • Biología celular
      • Cultivo celular
  • Ciencias médicas
    • Farmacodinámica
      • Mecanismos de acción de los medicamentos
    • Farmacología
      • Fitofármacos
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • The main objective of this thesis was to study the chemical profile of the algae Bifurcaria bifurcata and Codium tomentosum collected on the coast of Peniche (Portugal), evaluating the antioxidant, neuroprotective and anti-inflammatory activities of its main metabolites in an in vitro model of Parkinson's disease induced by the neurotoxin 6-hydroxydopamine on SH-SY5Y cells. This study allowed to identify 6 compounds, in which only 2 (eleganolone and loliolide) demonstrated to have neuroprotective and antiinflammatory potential. The results obtained in this work consisted of an initial approach in relation to the neuroprotective potential in a model of Parkinson's disease, allowing these compounds can studied in more complex models and to be used as pharmacological agents in the treatment of Parkinson's disease.