Epigenetic modulation of the immune system in early childhood: from infectious diseases to vaccines
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http://hdl.handle.net/10347/26993
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Título: | Epigenetic modulation of the immune system in early childhood: from infectious diseases to vaccines |
Autor/a: | Pischedda, Sara |
Dirección/Titoría: | Salas Ellacuriaga, Antonio Martinón Torres, Federico (dir.) |
Centro/Departamento: | Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS) Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular |
Palabras chave: | Epigenetics | Immune System | Childhood | Infectious Diseases | Vaccines | |
Data: | 2021 |
Resumo: | Epigenetic mechanisms regulate gene expression and transcription in a dynamic way. Many functional differences observed in the immune system of neonates and adults seem to be associated with epigenetic modifications of genes that control inflammation and immune response. One of the most studied epigenetic mechanisms is DNA methylation, considered as the major epigenetic factor influencing gene activities. Using the Infinium Illumina Methylation BeadChip platform it was possible to provide insights on the role of epigenetic mechanisms, especially DNA methylation alterations, in the different respiratory sequelae observed after RSV infection and in the variable immune response observed after PCV13 in early childhood. |
URI: | http://hdl.handle.net/10347/26993 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
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- Área de Ciencias da Saúde [1262]
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