Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy

• Autores: Helena Rouco Taboada
• Directores de la Tesis: Mariana Landín Pérez (dir. tes.), Carmen Remuñán López (codir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2021
• Idioma: español
• Tribunal Calificador de la Tesis: Ana Isabel Torres Suárez (presid.), Carlos Alberto García González (secret.), Ana Margarida Moutinho Grenha (voc.)
• Programa de doctorado: Programa de Doctorado en Investigación y Desarrollo de Medicamentos por la Universidad de Santiago de Compostela
• Materias:
  • Matemáticas
    • Ciencia de los ordenadores
      • Inteligencia artificial
  • Ciencias médicas
    • Farmacología
      • Composición de medicamentos
      • Preparación de medicamentos
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • In this work, we rationally developed a lipid-based nanotechnological platform for hydrophobic anti-mycobacterial drugs. For this purpose, Artificial Intelligence tools were employed to assist formulation development, from the initial design to its conversion into a solid dosage form. Reproducible nanocarriers exhibiting suitable properties were achieved through a simple and robust procedure. Furthermore, the analysis of their in vitro performance revealed promising results in terms of permeability, cell uptake and selective intracellular release. Thus demonstrating the potential of these nanosystems to treat intestinal intracellular infections, increasingly related with Crohn´s disease development.