Polymeric nanocapsules for the ocular delivery of siRNA
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http://hdl.handle.net/10347/20532
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Título: | Polymeric nanocapsules for the ocular delivery of siRNA |
Autor/a: | Mendes Saraiva, Sofia |
Dirección/Titoría: | Alonso Fernández, María José |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS) Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación e Desenvolvemento de Medicamentos |
Palabras chave: | Nanomedicine | protamine nanocapsules | siRNA | |
Data: | 2019 |
Resumo: | The development of siRNA-based therapies for the treatment of severe ocular diseases is being proposed as a promising therapeutic option for the treatment of severe ocular diseases. Unfortunately, the capacity of siRNA molecules to overcome the multiple protective barriers of the eye is very limited. The specific objective of this work was to develop multiplayer protamine NCs loading high amounts of siRNA (up to 5 mg/mL) for ocular topical administration. Different preparation methods and compositions were studied for the development of NCs complying with the requirements of drug loading and release and also in terms of stability. Among the multiple formulations developed, one of them led to acceptable silencing results in vitro and showed the ability to interact efficiently with the rabbits’ corneal epithelium. |
URI: | http://hdl.handle.net/10347/20532 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
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- Área de Ciencias da Saúde [1262]
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