Optimisation on novel methods for pre-clinical imaging at 11.7t

• Autores: Geraldine Pastor
• Directores de la Tesis: Torsten Reese (dir. tes.)
• Lectura: En la Universidad del País Vasco - Euskal Herriko Unibertsitatea ( España ) en 2017
• Idioma: inglés
• Tribunal Calificador de la Tesis: Jesus Mari Aizpurua Iparraguirre (presid.), María Iciar Martínez Galarza (secret.), Mathias Hoehn (voc.), Jesús Jiménez Barbero (voc.), Peter Morris CBE (voc.)
• Materias:
  • Física
    • Física atómica y nuclear
      • Resonancia magnética nuclear
  • Química
    • Bioquímica
      • Procesos metabólicos
  • Ciencias de la vida
    • Fisiología humana
      • Neurofisiología
• Enlaces
  • Tesis en acceso abierto en: ADDI
• Resumen

  • The aim of this research project was to describe and optimise the potential of fast magneticresonance imaging (MRI) methods at high field strength for in vivo studies. A zoomed UFLAREmethod have been implemented and compared to conventional fast methods forrelaxometry applications and presented for abdominal imaging. Then high resolutionangiography has been improved to visualise, in a non-invasive way, the cerebral vasculaturein six different rat strains. The protocol was then applied to an experimental stroke model.Finally, functional MRI technique has been used to study the shape of the hemodynamicresponse through the anaesthesia of medetomidine. The influence of anomers of D-glucosehave been then investigated. A cinematographic FLASH method was then upgraded forimproving the spatial and temporal resolution..