Nanoneuroprotection against glutamatergic excitotoxicity in ischemic stroke
Por favor, use este identificador para citas ou ligazóns a este ítem:
http://hdl.handle.net/10347/18044
Ficheiros no ítem
Metadatos do ítem
Título: | Nanoneuroprotection against glutamatergic excitotoxicity in ischemic stroke |
Autor/a: | Silva Candal, Andrés da |
Dirección/Titoría: | Castillo Sánchez José Antonio Campos Pérez, Francisco Sobrino Moreiras, Tomás |
Centro/Departamento: | Universidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía Universidade de Santiago de Compostela. Departamento de Fisioloxía |
Palabras chave: | Ictus isquémico | Glutamato | Nanoparticulas | |
Data: | 2018 |
Resumo: | Blood/brain-glutamate grabbing is an emerging concept in the treatment of acute ischemic stroke, where the deleterious effects of glutamate after ischemia are ameliorated by coaxing glutamate to enter the bloodstream and thus reducing its concentration in the brain. In this Thesis we resorted to a drug-repositioning strategy for the discovery of new glutamate-grabbing drugs, aiming to demonstrate the preclinical and clinical effect in ischemic stroke. The use of nanoparticles has emerged as a need to provide treatments for personalized nanomedicine through specific interactions at molecular levels. In this Thesis we optimize the active targeting of nanoparticles to an inducible target of endothelial cells in different experimental conditions of increasing complexity and tested the biocompatibility of new mesoporous nanostructures for drug delivery and contrast agent. |
URI: | http://hdl.handle.net/10347/18044 |
Dereitos: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Coleccións
-
- Área de Ciencias da Saúde [1262]
O ítem ten asociados os seguintes ficheiros de licenza: