Brain hypothermia in ischemic stroke: non-invasive thermometry and molecular basis
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http://hdl.handle.net/10347/15475
Título: | Brain hypothermia in ischemic stroke: non-invasive thermometry and molecular basis
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Autor/a: | Vieites Prado, Alba
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Dirección/Titoría: | Castillo Sánchez José Antonio
Campos Pérez, Francisco
Sobrino Moreiras, Tomás
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Centro/Departamento: | Universidade de Santiago de Compostela. Facultade de Bioloxía Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía e Saúde Pública
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Palabras chave: | Stroke | Therapeutic hypothermia | Non-invasive thermometry | RBM3 | |
Data: | 2017
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Resumo: | Ischemic stroke is a leading cause of death and morbidity around the world. However, only one pharmacological treatment is currently available, the tissue plasminogen activator or rtPA. Preclinical studies demonstrated the high therapeutic potential of hypothermia to mitigate the effects of stroke, but this therapy has not been successfully translated to the clinics due to the side effects associated to cold (shivering, arrhythmia, or pneumonia among others), and due to the lack of non-invasive methods to assess brain temperature. The present work provides new data about the therapeutic potential of focal brain hypothermia as alternative to systemic cooling, the use of non-invasive magnetic resonance thermometry to measure brain temperature, and the possible implication of RBM3, a cold shock protein, in the molecular process underlying the protective effect of cold. |
URI: | http://hdl.handle.net/10347/15475
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Dereitos: | Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
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