Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras
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Título: | Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras |
Autor/a: | Mosquera Mosquera, Jesús Rodríguez Villar, Jéssica Vázquez Sentís, Marco Eugenio Mascareñas Cid, José Luis |
Centro/Departamento: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares Universidade de Santiago de Compostela. Departamento de Química Orgánica |
Palabras chave: | DNA recognition | Molecular recognition | Oligonucleotides | Peptides | Supramolecular chemistry | |
Data: | 2014-04-24 |
Editor: | WILEY-VCH Verlag GmbH |
Cita bibliográfica: | Mosquera, J., Rodríguez, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras. ChemBioChem, 15: 1092–1095. doi: 10.1002/cbic.201400079 |
Resumo: | We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein failed to bind to DNA; however, modifications that increased the α-helical folding propensity of the peptide allowed specific DNA binding by a bipartite (major/minor groove) interaction |
Versión do editor: | http://dx.doi.org/10.1002/cbic.201400079 |
URI: | http://hdl.handle.net/10347/11967 |
DOI: | 10.1002/cbic.201400079 |
ISSN: | 1439-7633 |
Dereitos: | © WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
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