Respuesta de schizosaccharomyces pombe a la desestabilización de microtúbulos interfásicos
- Autores: Fernando Romero Balestra
- Directores de la Tesis: Juan Jiménez (dir. tes.)
- Lectura: En la Universidad Pablo de Olavide ( España ) en 2009
- Idioma: español
- Tribunal Calificador de la Tesis: Jaime Correa Bordes (presid.), Rafael Daga (secret.), Juan Ignacio Mata Monteagudo (voc.), María de la Cruz Muñoz Centeno (voc.), José Cansado Vizoso (voc.)
- Materias:
- Enlaces
- Tesis en acceso abierto en: TESEO
- Resumen
Microtubules assume a variety of structures throughout the different stages of the cell cycle. Ensuring the correct assembly of such structures is essential to guarantee cell division. During mitosis, it is well established that the spindle assembly checkpoint monitors the correct attachment of sister chromatids to the mitotic spindle. However, the role that microtubule cytoskeleton integrity plays for cell-cycle progression during interphase is uncertain. Here we describe the existence of a mechanism, independent of the mitotic checkpoint, that delays entry into mitosis in response to G(2)-phase microtubule damage. Disassembly of the G(2)-phase microtubule array leads to the stabilization of the universal mitotic inhibitor Wee1, thus actively delaying entry into mitosis via inhibitory Cdc2 Tyr15 phosphorylation.
