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Cristina González Aguilera
Email: Solicitar correo
Perfil en ORCID: 0000-0003-4845-5744
Perfil en Scopus: 2407050980

Grupo de Investigación: Metabolismo del DNA
Departamento/Unidad: Biología Celular
Situación profesional: Contratado Ramón y Cajal

Responsable de los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • La ruta Anemia de Fanconi y su papel en la estabilidad de la cromatina naciente durante los conflictos transcripción-replicación (US-1381081)
  • Efecto de la Replicación de la Cromatina en la Expresión Génica (PID2019-105743GA-I00)
  
  

Participa en los siguientes proyectos/ayudas en la US:

• Proyecto de investigación:
  • Bases Genéticas y Moleculares del Origen de la Inestabilidad Genomica en Eucariotas (P09-CVI-4567 - Otro Investigador)
  • Inestabilidad genómica (CSD2007-00015 - Contratado)
  • Genómica Funcional de la Interconexión Transcripción -Transporte de ARN (P07-CVI-02549 - Otro Investigador)
  • Bases genéticas y moleculares de la inestabilidad genómica y su relación con la biogénesis de los mRNPs de eucariotas (BFU2006-05260 - Otro Investigador)
  • Bases genéticas y moleculares del origen de la inestabilidad genética en eucariotas (EXC/2005/CVI-624 - Otro Investigador)
  • Inestabilidad genética asociada a transcripción en eucariotas (SAF2003-00204 - Becario)
  
  
• Ayuda a la investigación:
  • Ayuda a la Consolidación del Grupo de Investigación BIO-102 (2008/BIO-102 - Investigador)
  • Ayuda a la Consolidación del Grupo de Investigación BIO-102 (2007/BIO-102 - Investigador)
  • Vigilancia del ARN nuclear en la expresión génica (BFU2007-28647-E - Becario)
  • Ayuda a la Consolidación del Grupo de Investigación CVI-102 (2005/CVI-102 - Investigador)
  
  

Cobertura de la base de datos de proyectos, véase aqui

Publicaciones:

Publicaciones en Revistas

Gylling, Hm, González Aguilera, Cristina, Smith, Ma, Kaczorowski, D.c., Groth, Anja, et. al.:
Repeat RNAs associate with replication forks and post-replicative DNA. En: RNA. 2020. Vol. 26. Núm. 9. Pag. 1104-1117. doi: 10.1261/rna.074757.120

Reverón Gómez, Nazaret, González Aguilera, Cristina, Stewart Morgan , Kathleen, Petryk , Nataliya, Flury , Valentine, et. al.:
Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication. En: Molecular Cell. 2018. Vol. 72. Núm. 2. Pag. 239-249. 10.1016/j.molcel.2018.08.010

Feng, y, Vlassis , a, Roques , C, Lalonde , Me, González Aguilera, Cristina, et. al.:
BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. En: EMBO Journal. 2016. Vol. 35. Núm. 2. Pag. 176-192. 0.15252/embj.201591293.

Huang, H, Strømme, Caroline, Saredi, Giulia, Hödl, Martina, Strandsby, Anne, et. al.:
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. En: Nature Structural and Molecular Biology. 2015. Vol. 22. Núm. 8. Pag. 618-626. 10.1038/nsmb.3055

Tena Aguilar, Juan Jesús, González Aguilera, Cristina, Fernández Miñan, Ana, Vázquez Marín, Javier, Parra Acero, Helena, et. al.:
Comparative epigenomics in distantly related teleost species identifies conserved cis-regulatory nodes active during the vertebrate phylotypic period. En: Genome Research. 2014. Vol. 24. Núm. 0. 10.1101/gr.163915.113

Santos Pereira, José María, Garcia Rubio, Maria Luisa, González Aguilera, Cristina, Luna Varo, Rosa Maria, Aguilera Lopez, Andres:
A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions. En: Nucleic Acids Research. 2014. Vol. 42. Núm. 19. Pag. 12000-12014

González Aguilera, Cristina, Ikegami, Kohta, Ayuso García, Cristina, De Luis, Alberto, Iñiguez, Maria, et. al.:
Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans. En: GenomeBiology.com. 2014. Vol. 15. 10.1186/gb-2014-15-2-r21

González Aguilera, Cristina, Palladino, Francesca, Askjaer, Peter:
Review/Reseña: C. elegans epigenetic regulation in development and aging. En: Briefings in Functional Genomics. 2013. Vol. 13. Núm. 3. Pag. 223-234. 10.1093/bfgp/elt048

González Aguilera, Cristina, Askjaer, Peter:
Review/Reseña: Dissecting the NUP107 complex - Multiple components and even more functions. En: Nucleus. 2012. Vol. 3. Núm. 4. Pag. 1-9. http://dx.doi.org/10.4161/nucl.21135

Towbin, Benjamin, González Aguilera, Cristina, Sack, Ragna, Gaidatzis, Dimos, Kalck, Veronique, et. al.:
Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery. En: Cell. 2012. Vol. 150. Pag. 934-947. http://dx.doi.org/10.1016/j.cell.2012.06.051

Rodenas Martinez, Eduardo, González Aguilera, Cristina, Ayuso García, Cristina, Askjaer, Peter:
Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in C. elegans. En: Molecular Biology of the Cell. 2012. Vol. 23. Pag. 930-944. doi:10.1091/mbc.E11-11-0927

Jimeno Gonzalez, Sonia, Garcia Rubio, Maria Luisa, Ranes, Michael, González Aguilera, Cristina, Marin Rodriguez, Antonio, et. al.:
New Suppressors of THO Mutations Identify Thp3 (Ypr045c)-Csn12 As a Protein Complex Involved in Transcription Elongation. En: Molecular and Cellular Biology. 2011. Vol. 31. Núm. 4. Pag. 674-685

Tous Rivera, Cristina, García Rondón, Ana, Garcia Rubio, Maria Luisa, González Aguilera, Cristina, Luna Varo, Rosa Maria, et. al.:
A Novel Assay Identifies Transcript Elongation Roles for the Nup84 Complex and RNA Processing Factors. En: EMBO Journal. 2011. Vol. 30. Pag. 1953-1964

González Aguilera, Cristina, Babiano, Reyes, De la Cruz, Jesus:
Nab2 Functions in the Metabolism of RNA Driven by Polymerases II and III. En: Molecular Biology of the Cell. 2011

González Aguilera, Cristina, Tous Rivera, Cristina, Babiano, Reyes, Cruz Diaz, Jesus de la, Luna Varo, Rosa Maria, et. al.:
Nab2 Functions in the Metabolism of RNA Driven by RNA Polymerases II and III. En: Molecular Biology of the Cell. 2011. Vol. 22. Pag. 2729-2740

Faza, Marius Boulos, Kemmler, Stefan, Jimeno Gonzalez, Sonia, González Aguilera, Cristina, Aguilera Lopez, Andres, et. al.:
Sem1 is a Functional Component of the Nuclear Pore Complex-Associated Messenger RNA Export Machinery. En: Journal of Cell Biology. 2009. Vol. 184. Núm. 6. Pag. 833-846

Gaillard, Helene, Tous Rivera, Cristina, Botet, J, González Aguilera, Cristina, Quintero, M J, et. al.:
Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: a New Role for Paf and Ccr4-Not in Transcription-Coupled Repair. En: PLoS Genetics. 2009. Vol. 5. Núm. 2

Luna Varo, Rosa Maria, González Aguilera, Cristina, Aguilera Lopez, Andres:
Review/Reseña: Transcription At the Proximity of the Nuclear Pore: a Role for the Thp1-Sac3-Sus1-Cdc31 (Thsc) Complex. En: RNA Biology. 2009. Vol. 6. Núm. 2. Pag. 145-148

Luna Varo, Rosa Maria, Gaillard, Helene, González Aguilera, Cristina, Aguilera Lopez, Andres:
Biogenesis of Mrnps: Integrating Different Processes in the Eukaryotic Nucleus. En: Chromosoma. 2008. Vol. 117. Núm. 4. Pag. 319-331

González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Huertas Sanchez, Pablo, Luna Varo, Rosa Maria, et. al.:
The Thp1-Sac3-Sus1-Cdc31 Complex Works in Transcription Elongation-Mrna Export Preventing RNA-Mediated Genome Instability. En: Molecular Biology of the Cell. 2008. Vol. 19. Núm. 10. Pag. 4310-4318

Aportaciones a Congresos

González Aguilera, Cristina, Reverón Gómez, Nazaret, Stewart Morgan, Kathleen, Petryk, Nataliya, Flury, Valentine, et. al.:
ChORseq: a new technology to study chromatin and chromatin bound proteins dynamics during DNA replication. Poster en Congreso. Trends in Genome integrity and chromosome dynamics. Sevilla, España. 2020

González Aguilera, Cristina:
Epigenome maintenance in proliferating cells. Ponencia en Congreso. Biotec Forum 2018: Biophysics in the nucleus. Dresden (Alemanha). 2018

Santos Pereira, José María, Garcia Rubio, Maria Luisa, González Aguilera, Cristina, Luna Varo, Rosa Maria, Aguilera Lopez, Andres:
A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions. Poster en Congreso. RNA Meets DNA: on the Road to Genome Instability. 2014

González Aguilera, Cristina, Gomez Saldivar, Georgina, Ayuso García, Cristina, Askjaer, Peter:
Genome-wide analysis links emerin to neuromuscular junction activity in C. elegans. Poster en Congreso. EMBO Nuclear Structure and Dynamics 2013. 2013

González Aguilera, Cristina, Askjaer, Peter:
Genome-wide analyses of lamin and emerin associated chromatin domains in C. elegans reveal global similarities and unique local enrichments. Ponencia en Congreso. ABCAM Chromatin, Replication and Chromosomal Stability 2013. 2013

Gomez Saldivar, Georgina, Fernandez, Anita, Lai, C, Bock, C, González Aguilera, Cristina, et. al.:
Functional Dissection of MEL-28, a Chromatin-Binding Protein with Essential Roles in Nuclear Envelope Function and Chromosome Segregation. Poster en Congreso. 19th International C. elegans meeting 201. California State University of los Angeles. los Angeles (EEUU). 2013

González Aguilera, Cristina, Ikegami, Kohta, De Luis, Alberto, Iñiguez, Maria, Cabello, Juan, et. al.:
Maps of lamin and emerin associated chromatin domains in C. elegans reveal global similarities and unique local enrichments. Ponencia en Congreso. 4th Spanish C. elegans Meetin. 2013

Gomez Saldivar, Georgina, González Aguilera, Cristina, Askjaer, Peter:
Functional characterization of MEL-28/ELYS. Ponencia en Congreso. 4th Spanish C. elegans Meetin. 2013

González Aguilera, Cristina, Ikegami, Kohta, De Luis, Alberto, Íñiguez, Maria, Cabello, Juan, et. al.:
Maps of lamin and emerin associated chromatin domains in C. elegans reveal global similarities and unique local enrichments. Poster en Congreso. Dynamic Organization of Nuclear Function. 2012

González Aguilera, Cristina, Askjaer, Peter:
Identification of the LMN-1 and EMR-1 DNA binding sites reveal the genome organization at the nuclear envelope in C. elegans. Poster en Congreso. 22nd IUBMB & 37th FEBS Congress. Palacio de Congresos Sevilla. 2012

González Aguilera, Cristina, Askjaer, Peter:
Identification of new DNA targets of nuclear envelope proteins in C. elegans using the DamID technique. Poster en Congreso. 18th International C. elegans meeting 201. Los Angeles, Ca. EEUU. 2011

González Aguilera, Cristina, Askjaer, Peter:
Identification of new DNA targets of nuclear envelope proteins in C. elegans using the DamID technique. Poster en Congreso. EMBO Workshop Chromatin Structure, Organization and Dynamics. 2011

Rodenas Martinez, Eduardo, González Aguilera, Cristina, Askjaer, Peter:
Nucleoporin Nup107/Npp-5 Interacts With Spindle Assembly Checkpoint Protein Mad1/Mdf-1 to Control Mitosis and Kinetochore Function. Poster en Congreso. C. Elegans Development and Gene Expression. Embl, Heidelberg, Alemania. 2010

Rodenas Martinez, Eduardo, González Aguilera, Cristina, Askjaer, Peter:
Nucleoporin Nup107/Npp-5 Interacts With Spindle Assembly Checkpoint Protein Mad1/Mdf-1 to Control Mitosis and Kinetochore Function. Poster en Congreso. Embo Meeting. 2010

González Aguilera, Cristina, Tous Rivera, Cristina, Babiano, Reyes, Cruz Diaz, Jesus de la, Luna Varo, Rosa Maria, et. al.:
Nab2 Functions in RNA Polymerase II Transcription and RNA Polymerase III RNA Metabolism. Poster en Congreso. Esf-Embo Conference on RNA Quality Control. Vienna, Austria. 2010. Esf-Embo Conference on RNA Quality Control. 0. 0

Tous Rivera, Cristina, Ranes, Michael, Jimeno Gonzalez, Sonia, Garcia Rubio, Maria Luisa, González Aguilera, Cristina, et. al.:
Revisiting Transcription Elongation: New Factors and New Links to Mrna Biogenesis. Conferencia Congreso no publicada. Embo Conference Series on Gene Transcription in Yeast. San Feliu de Guixols, España. 2010. Embo Conference Series on Gene Transcription in Yeast. 24. 24

Garcia Rubio, Maria Luisa, Jimeno Gonzalez, Sonia, Tous Rivera, Cristina, Ranes, Michael, González Aguilera, Cristina, et. al.:
New Suppressors of THO Mutations Identify Thp3-Csn12 As a Protein Complex Involved in Transcription. Poster en Congreso. Embo Conference Series on Gene Transcription in Yeast. San Feliu de Guixols, España. 2010. Embo Conference Series on Gene Transcription in Yeast. 73. 73

Luna Varo, Rosa Maria, González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Garcia Rubio, Maria Luisa, et. al.:
Biogenesis de Mrnps y Elongacion de la Transcripcion: Thsc y Nab2 en la Interfase Transcripcion y Transporte del Arnm (Or3). Comunicación en congreso. XXXVII Congreso de la Sociedad Española de Genetica. Torremolinos,Malaga. 2009. XXXVII Congreso de la Sociedad Española de Genetica. 0. 0

Luna Varo, Rosa Maria, González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Aguilera Lopez, Andres:
Novel Insights Into the Connection of Transcription With RNA Export. Comunicación en congreso. Embo Workshop on Mechanisms of Nucleocytoplasmic Transport. Taormina Sicily. 2007. Embo Workshop on Mechanisms of Nucleocytoplasmic Transport. 0. 0

Luna Varo, Rosa Maria, González Aguilera, Cristina, Tous Rivera, Cristina, Gómez González, Belén, Aguilera Lopez, Andres:
Thp1-Sac3-Sus1 and Mex67 Works in Transcription Elongation-Mrna Export Preventing R-Loop Formation and Genome Instability. Comunicación en congreso. Reunión de la Red Española de Levaduras. El Escorial (Madrid). 2007. Reunión de la Red Española de Levaduras (Resúmenes). 0. 0

Gomez Saldivar, Georgina, González Aguilera, Cristina, Askjaer, Peter:
Nuclear pore complex protein MEL-28 associates with active chromatin and regulates chromosome segregation and nuclear envelope assembly. Poster en Congreso

González Aguilera, Cristina, Gomez Saldivar, Georgina, Askjaer, Peter:
Exploring a novel function of emerin in neuromuscular junction activity. Ponencia en Congreso

Gomez Saldivar, Georgina, González Aguilera, Cristina:
Functional characterization of MEL-28/ELYS. Ponencia en Congreso