Resumen de Aurresan ezin den Estres Kroniko Moderatua (Chronic Unpredictable Mild Stress, CUMS): depresioaren animalia-eredua

Ines Erkizia Santamaria, Jorge E. Ortega Calvo, Igor Horrillo Furundarena

• English

  Depression is one of the most relevant mental diseases in current society. Its neurobiological baseshave yet not been elucidated, but it is well known that biological and environmental factors play animportant role in the development of the condition. Stress has been established as one of the maincontributors, as research studies have correlated it with the disease. Animal models are essential forthe research of psychiatric disorders. In this case, an animal model based on the exposure to chronicstress has been developed. Chronic Unpredictable Mild Stress (CUMS) is a widely used rodent modelof depression, which has high validity. In the current study, the model has been produced andevaluated through behavioural tests and biological marker measurements.

• euskara

  Depresioa gaixotasun mental garrantzitsuenetakoa da egungo gizartean. Haren oinarrineurobiologikoak erabat argi ez dauden arren, bai faktore biologikoek, bai ingurumenekoek eredepresioa garatzeko arriskua areagotzen dutela jakina da. Azken hauen artean aipatzekoa da estresa,ikerketa anitzek deskribatu baitute estresaren eta depresioaren arteko erlazioa. Gaixotasunpsikiatrikoen ikerketarako funtsezkoak dira animalia-ereduak. Kasu honetan, estres kronikoa eragiteanoinarritzen den animalia-eredu baten garapena burutu da. Chronic Unpredictable Mild Stress (CUMS)baliotasun handiko depresioaren eredua da, karraskarietan erabiltzen dena. Ikerketa honetan, portaerafrogenbidez nahiz markatzaile biologikoak neurtuz, animalia-ereduaren ebaluazioa burutu dugu.