The multiple facets of the club cell in the pulmonary epithelium

• Nelly López-Valdez ^[1] ; Marcela Rojas-Lemus ^[1] ; Patricia Bizarro-Nevares ^[1] ; Adriana González-Villalva ^[1] ; Brenda Casarrubias-Tabarez ^[1] ; María Eugenia Cervantes-Valencia ^[1] ; Martha Ustarroz-Cano ^[1] ; Guadalupe Morales-Ricardes ^[1] ; Shamir Mendoza-Martínez ^[1] ; Gabriela Guerrero-Palomo ^[2] ; Teresa I Fortoul ^[1]
  1. [1] School of Medicine, UNAM, Ciudad de México, México
  2. [2] Independent Researcher
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 39, Nº. 8, 2024, págs. 969-982
• Idioma: inglés
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• Resumen

  • The non-ciliated bronchiolar cell, also referred to as “club cell”, serves as a significant multifunctional component of the airway epithelium.

    While the club cell is a prominent epithelial type found in rodents, it is restricted to the bronchioles in humans.

    Despite these differences, the club cell's importance remains undisputed in both species due to its multifunctionality as a regulatory cell in lung inflammation and a stem cell in lung epithelial regeneration.

    The objective of this review is to examine different aspects of club cell morphology and physiology in the lung epithelium, under both normal and pathological conditions, to provide a comprehensive understanding of its importance in the respiratory system.