Resumen de Ultrastructural changes of the choroid plexus of the lateral ventricles of rats (rattus norvegicus) submitted to experimentalchronic alcoholism, followed by alcohol withdrawal
Luis Fernando Tirapelli, O. J Tamega, Francisco E. Martinez
- español
Cuarenta ratas machos adultas se dividieron en dos grupos de 20 animales cada uno (grupos control y experimentales). El grupo experimental recibió alcohol de caña de azúcar comercial, marca "51 Pirassununga", diluida a 30 g/L como dieta líquida por un período de 240 días y agua potable por los siguientes 60 días. Los animales se sacrificaron después de 60, 120, 180, 240 y 300 días de tratamiento. Se observaron varios cambios morfológicos en el grupo experimental de animales de hasta 240 días de tratamiento, encontrándose dilatación de las cisternas del retículo endoplasmático rugoso, espacios intercelulares aumentados, espacios entre las interdigitaciones basolaterales de las células, inflamación del tejido conjuntivo y presencia de una gran cantidad de células pinocíticas, de vacuolas digestivas y de vesículas con contenido electrolúcido a lo largo del citoplasma.
- English
Forty adult male rats were divided into two groups of 20 animals each, i.e., control (C) and experimental groups (Ep). Group Ep received sugar cane brandy commercially make, "brand 51 Pirassununga", diluted to 30 G.L. as a liquid diet for a period of 240 days, and tap water for the subsequent 60 days. The animals were sacrificed after 60, 120, 180, 240 and 300 days of treatment. Several morphologic changes were observed in Group Ep animals up to 240 of treatment, i.e., dilatation of the cisterns of the rough endoplasmic reticulum, increased intercellular spaces between the basolateral interdigitations of the cells, swelling of the connective tissue, and presence of a large amount of pinocytic cells, of digestive vacuoles and of vesicles with electronlucent content throughout the cytoplasm. After 300 days of treatment Group Ep animals presented a significant regression of the above changes. No changes were observed in Group C animals.
