Biological activities and correlations tendency of electrochemical properties of some indolizino[1,2-b]quinoline derivatives

• A CAÑETE ^[1] ; F ARMIJO ^[1] ; M. A DEL VALLE ^[1] ; R.A TAPIA ^[1] ; C THEODULOZ ^[2] ; C. D PESSOA ^[1] ; L CANTUARIAS ^[1] ; G RECABARREN ^[1]
  1. [1] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  2. [2] Universidad de Talca

     Universidad de Talca

     Provincia de Talca, Chile

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 57, Nº. 2, 2012, págs. 1126-1129
• Idioma: inglés
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• Resumen

  • We report the preparation of a series of indolylquinone and pyridine derivatives in order to evaluate structure-activity relationships in human gastric (AGS), lung (SK-MES-1), bladder (J82) cancer cell lines and human normal lung fibroblasts (MCR-5). Two correlations tendency between half-wave redox potentials against their antineoplasic activity were found making it possible to establish that for epithelial human gastric cancer (AGS) cell lines and human normal lung fibroblasts (MCR-5). The quinone bioreduction should correspond to a one electron process under normomix conditions, whilst for all other lines this process should correspond to a two electron attachment via a hypoxic process.