Resumen de Management of liver and gastrointestinal toxicity induced by immune checkpoint inhibitors: Position statement of the AEEH-AEG-SEPD-SEOM-GETECCU

Mar Riveiro Barciela, Sabela Carballal Ramil, Álvaro Díaz González, Míriam Mañosa, Javier Gallego Plazas, Joaquín Cubiella Fernández, P. Jiménez Fonseca, María Varela, Luis Alberto Menchén, Bruno Sangro Gómez Acebo, Ana Fernández Montes, Francisco Mesonero Gismero, Miguel Ángel Rodríguez Gandía, Fernando Rivera Herrero, María Carlota Londoño Hurtado

• The development of the immune checkpoint inhibitors (ICI) is one of the most remarkable achievements in cancer therapy in recent years. However, their exponential use has led to an increase in immune-related adverse events (irAEs). Gastrointestinal and liver events encompass hepatitis, colitis and upper digestive tract symptoms accounting for the most common irAEs, with incidence rates varying from 2 % to 40 %, the latter in patients undergoing combined ICIs therapy. Based on the current scientific evidence derived from both randomized clinical trials and real-world studies, this statement document provides recommendations on the diagnosis, treatment and prognosis of the gastrointestinal and hepatic ICI-induced adverse events.