Abstract
Aims: In heart failure (HF) patients, anemia and iron deficiency (ID) are predictors of poor outcome. We studied the association of anemia, ID and related hematological parameters with short-term rehospitalization, short-term all-cause mortality and end of follow-up all-cause mortality in HF patients.
Material and Methods: Anemia, ID, red cell distribution width (RDW) and erythropoietin (EPO) were assessed in patients hospitalized with acute decompensated heart failure (ADHF). Univariate Cox proportional hazard model was used to assess the relationship between variables and outcomes.
Results: 65 patients were followed for a median of 13.7 (Q1-Q3 6.7-18.9) months. Mean age was 79.2 (SD 10.8) years. The mean left ventricular ejection fraction (LVEF) was 50.38 ± 19.07 %. Variables associated with an increased risk for short-term rehospitalization were RDW (hazards ratio [HR] 1.35; 95% confidence interval [CI] 1.16-1.58), anemia (HR 3.81; 95% CI 1.29-11.28) and anemia with ID (HR 3.50; 95% CI 1.30-9.38). Increased risk for short-term mortality was associated with RDW (HR 1.83; 95% CI 1.29-2.59), EPO (HR 1.38; 95% CI 1.04-1.82), absolute ID (HR 7.22; 95% CI 1.50-34.81) and anemia with ID (HR 4.48; 95% CI 1.26-15.88). Variables associated with increased risk for end of follow-up mortality were RDW (HR 1.31; 95% CI 1.12-1.54) and EPO (HR 1.29; 95% CI 1.11-1.49).
Conclusions: Anemia and RDW correlated with higher risk for short-term rehospitalization. Absolute iron deficiency, RDW and EPO were associated with higher risk for short-term mortality. RDW and EPO were associated with higher risk for end of follow-up mortality.
© 2022 Galicia Clínica.
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