Resumen de Hybrid lipid/clay carrier system containing Bixa orellana L.: a tool for drug delivery
Raquel de Melo Barbosa, Fátima García Villén, Fernanda Nervo Raffin, César Viseras Iborra, Tulio Moura
Nanocomposite systems attract considerable interest in the pharmaceutic and cosmetic fields due to the wide range of advantageous properties compared to free polymers, such as the high potential to provide predictable, accurate, and reproducible patterns of controlled release and specific delivery of bioactive molecules. Studies have shown the hybridization of different clays with polymers or surfactants by strong secondary interactions of the mineral compounds with their guests. Nanostructured lipid carriers (NLC) associated with clays have gained attention in pharmaceutical areas due to their ability to transport hydrophobic drugs. Additionally, lipid-based nanoparticles are considering “nano-safety, stable, biocompatible, and have low dermal toxicity. In this context, Bixa orellana L. or “annatto,” has been proposed as a potential active ingredient in pharmaceuticals by its biological activity as healing, antioxidant, antibacterial, and anti-leishmaniasis properties. The purpose of the present study was to produce and characterize NLCs with AO in association with Laponite (L) nanoparticles (Na+ 0.7[(Si8 Mg5.5Li0.3) O20(OH)4 ]-0.7).
