Cannabis-based terpenes loaded in PEG-PLGA nanoparticles for pain management

• Mazen M El-Hammadi ^[1] ; Small Howard AL ^[3] ; Mercedes Fernández Arévalo ^[1] ; Lucía Martín Banderas ^{[1] [2]}
  1. [1] Universidad de Sevilla

     Universidad de Sevilla

     Sevilla, España

     
  2. [2] Hospital Universitario Virgen del Rocío

     Hospital Universitario Virgen del Rocío

     Sevilla, España

     
  3. [3] GB Sciences, Inc. (OTCQB:GBLX), 3550 W. Teco Avenue, Las Vegas, NV, USA

  Mostrar afiliaciones +
• Localización: RESCIFAR Revista Española de Ciencias Farmacéuticas, ISSN-e 2660-6356, Vol. 2, Nº. 2, 2021 (Ejemplar dedicado a: XV CONGRESO DE LA SOCIEDAD ESPAÑOLA DE FARMACIA INDUSTRIA Y GALÉNICA), págs. 198-199
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • In the recent decade, more attention has been paid to the cannabis-based extracts and products to fill the gap left by analgesics currently available in the clinic. The resin of Cannabis sativa is highly rich in terpenes, many of which have been found to exert various biological activities. Among terpenes found in cannabis, beta-myrcene, beta-caryophyllene and nerolidol may be promising in pain management1 However, the volatile and hydrophobic nature, and associated poor solubility and low bioavailability, may limit their suitability as pharmaceutical agents. We hypothesized that the encapsulation of these terpenes in polymeric nanoparticles may enhance their pharmacological effects, in particular in pain management.