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A strategic reflection for the management and implementation of CAR-T therapy in Spain: an expert consensus paper

    1. [1] Universidad de Las Palmas de Gran Canaria

      Universidad de Las Palmas de Gran Canaria

      Gran Canaria, España

    2. [2] Hospital Universitario Virgen Macarena

      Hospital Universitario Virgen Macarena

      Sevilla, España

    3. [3] Universidad Complutense de Madrid

      Universidad Complutense de Madrid

      Madrid, España

    4. [4] Hospital de la Santa Creu i Sant Pau

      Hospital de la Santa Creu i Sant Pau

      Barcelona, España

    5. [5] Health Economics Department, Weber Economía y Salud, C/Moreto 17, 5D, 28014, Madrid, Spain
    6. [6] The Spanish Society of Health Executives, Sociedad Española de Directivos de La Salud (SEDISA), Madrid, Spain
    7. [7] Hematology Service, CIBERONC, and Salamanca Cancer Research Centre-IBMCC (USAL-CSIC), University Hospital of Salamanca (HUS/IBSAL), Salamanca, Spain
    8. [8] Medical Oncology Service, Navarra Hospital Complex, Navarra Hospital, Pamplona, Navarra, Spain
    9. [9] Department of Economic Analysis and Finance, University of Castilla-La Mancha, Toledo, Spain
  • Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 24, Nº. 6 (junio), 2022, págs. 968-980
  • Idioma: inglés
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  • Resumen
    • CAR-T cell therapy represents a therapeutic revolution in the prognosis and treatment of patients with certain types of hematological cancer. However, they also pose new challenges in the healthcare, regulatory and financial fields. The aim of the RET-A project was to undertake a strategic reflection on the management of CAR-T therapies within the Spanish National Health System, to agree on recommendations that will help to better deal with the new context introduced by these cell therapies in the present and in the future. This think tank involved 40 key agents and opinion leaders. The experts identified three great challenges for implementing advanced therapies in Spain: therapeutic individualisation, with a multidisciplinary approach; acceleration of access times, by minimizing bureaucracy; and increase in the number of centers qualified to manage the CAR-T therapies in the NHS. The experts agreed on the ideal criteria for designating those qualified centers. They also agreed on a comprehensive CAR-T care pathway with the timings and roles which would ideally be involved in each part of the process.


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