Resumen de Tissue Engineering for modeling Epidermolysis Bullosa- Squamous Cell Carcinomas
A. González, S. Guerrero Aspizua, C.J. Conti, M. García, E. Chacón Solano, Fernando Larcher, M. Rio Sevilla
Recessive Dystrophic Epidermolysis Bullosa is a rare genodermatosis characterized, among other characteristics, by the presence of cutaneous blisters and the appearance of Squamous Cell Carcinomas that are very aggressive with a rapid lethal outcome; becoming the principal cause of mortality for this disease [1], [2]. Nowadays, there is not treatment neither for its original genetic mutation, or skin blisters nor for their associated tumors, and the short lifetime of these patients with diagnosed cancer, make very difficult to carry out clinical trials [3], [4]. Therefore, in order to evaluate new therapeutic approaches, it is necessary to develop new organotypic models that recapitulates the pathological features of the disease, with a great emphasis on the stroma composition that has been pointed as a key factor for the malignity [2], [5]–[10]. In this work, by use of Tissue Engineering, a Squamous Cell Carcinoma model was generated. Our characterization showed that the bioengineered humanized xenotransplants, resemble the characteristics of the original RDEB-SCC stroma, being a good approach to further understand the pathology and to test antineoplastic drugs directed primarily against the stroma of the tumors.
