Enzyme Free Energy Diagrams: Enzyme–Substrate Binding Is Always Spontaneous

• Todd P. Silverstein ^[1]
  1. [1] Willamette University

     Willamette University

     Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 98, Nº 3, 2021, págs. 1049-1051
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • In at least two papers published in this Journal, enzyme free energy diagrams were presented showing enzyme–substrate binding to be nonspontaneous. I present here several different approaches showing that enzyme–substrate binding is always spontaneous, and the y-axis of the reaction progress diagrams presented previously is in fact standard enthalpy (H°), and not free energy.