Resumen de Shedding of BAFF/APRIL receptors controls b cells

Edgar Meinl, Franziska S. Thaler, Stefan F. Lichtenthaler

• Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma