Whipple´s disease, a rare malabsorption syndrome of late diagnosis.

• Autores: Raquel Batista, André Real, Jorge Nepomuceno, Maria de Fátima Pimenta
• Localización: Galicia Clínica, ISSN 0304-4866, ISSN-e 1989-3922, Vol. 79, Nº. 3 (Septiembre), 2018, págs. 89-91
• Idioma: inglés
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• Resumen

  • Whipple´s disease is a rare, chronic bacterial illness with multisystemic involvement, caused by Tropheryma whipplei. Due to it´s multiform presentation and rarity it is often misdiagnosed. The standard method concerning diagnosis is the detection of PAS (periodic acid- Shiff) positive macrophages in affected tissues.Immunohistochemical staining and PCR (polymerase chain reaction) increase the sensitivity and specificity of conventional methods.

    Long term antibiotic therapy provides a favourable outcome in the majority of cases. The autors describe a case of a patient with Whipple´s disease in a progressive stage.