This article discusses research indicating that small changes in DNA can sometimes result in significant changes in an organism. Research in nucleotide sequencing that discovered a connection between a silent genetic mutation and health problems such as Marfan syndrome, Hirschsprung disease, and phenylketonuria is described. The effect of these mutations was found by examining mistranslation by messenger RNA in the protein production process. INSETS: BROKEN SILENCE;SILENCE IN THE CODE;SPLICING CUES ALTERED;Biased Vaccine
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