Risk sciences involve increasingly optics applications to perform accurate analysis of critical behavior such as failures, explosions, fires. In this particular context, different area sizes are investigated under high temporal sampling rate up to 10000fps. With the improvement of light sources and optical sensors, it is now possible to cope with high spatial resolution even for time resolved measurement. The paper deals with the study of the interaction between overpressure waves, occurring in case of explosion for example, with a liquid droplet present in the vicinity of the overpressure wave. This is a typical scenario encountered in case of industrial breakdown including liquid leakage and explosions. We designed an experimental setup for the evaluation of the interaction between the overpressure wave and falling liquid droplets. A gas chamber is filled with nitrogen until breakage of the outlet rupture disk at about 4 bar. The droplets fall is controlled by an automatic syringe injector placed in the overpressure wave. The imaging system is based on laser shadowscopy. The laser source is a double cavity 15mJ- 1000Hz Nd YLF laser emitting double pulses of about 10ns at 527nm. To record the double pulse after crossing the falling droplets, the transmitted light is captured by a lasersynchronized double frame camera. Since these measurements are time-synchronized, it is then possible to know accurately the different parameters of the phenomenon, such as overpressure wave velocity, droplets diameter, and Reynolds number. Different experiments have been carried out at about 4000 doubleframe/s. The paper presents the whole experiment, the enhancements of the setup and the results for different liquid products from water to acetone
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